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J Infect Dis ; 223(2): 192-196, 2021 02 03.
Artículo en Inglés | MEDLINE | ID: covidwho-1060994

RESUMEN

At the start of the UK coronavirus disease 2019 epidemic, this rare point prevalence study revealed that one-third of patients (15 of 45) in a London inpatient rehabilitation unit were found to be infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) but asymptomatic. We report on 8 patients in detail, including their clinical stability, the evolution of their nasopharyngeal viral reverse-transcription polymerase chain reaction (RT-PCR) burden, and their antibody levels over time, revealing the infection dynamics by RT-PCR and serology during the acute phase. Notably, a novel serological test for antibodies against the receptor binding domain of SARS-CoV-2 showed that 100% of our asymptomatic cohort remained seropositive 3-6 weeks after diagnosis.


Asunto(s)
COVID-19/diagnóstico , COVID-19/inmunología , Nasofaringe/virología , Centros de Rehabilitación/estadística & datos numéricos , SARS-CoV-2/aislamiento & purificación , Anticuerpos Antivirales/sangre , Formación de Anticuerpos , Infecciones Asintomáticas/epidemiología , COVID-19/epidemiología , COVID-19/virología , Estudios de Cohortes , Femenino , Humanos , Londres/epidemiología , Masculino , Persona de Mediana Edad , SARS-CoV-2/inmunología , Pruebas Serológicas
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